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| Date & Location | Speakers |
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January 29, 2010 3:30 PM–5:00 PM Meyer 815 |
Thomas Thesen Detection of epileptogenic cortical malformations with surface-based MRI morphometry Magnetic resonance imaging has revolutionized the detection of small structural abnormalities in patients with epilepsy. However, many focal abnormalities remain undetected in routine radiological inspection. We introduce a quantitative method using morphometric features related to epileptogenic cortical malformations to detect aberrant cortical thickness and blurred gray-white matter boundaries. Using MRI morphometry at 3T with surface-based spherical averaging techniques that precisely align anatomical structures between individual brains, we compared single patients with known lesions to a large normal control group to detect clusters of abnormal cortical thickness and gray-white matter contrast (GWC). To assess the effects of threshold and smoothing on detection sensitivity and specificity, we systematically varied these parameters with 13 different thresholds and 3 smoothing levels. Structural abnormalities detected by this method were compared to intracranial EEG, pathological cell markers using post-resection histology and surgical outcome. With optimal parameters and by combining thickness and GWC, the surface-based detection method identified 92% of cortical lesions (sensitivity) with few false positives (96% specificity), successfully discriminating patients from controls 94% of the time. The detected structural abnormalities were related to the seizure onset zones, abnormal histology and positive outcome in all surgical patients. This automated approach may be a valuable clinical tool to detect previously occult malformations and improve identification of patients with intractable focal epilepsy that may benefit from surgery. |
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Feb 5, 2010 |
No Meeting |
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Feb 12, 2010 3:30 PM–5:00 PM Meyer 815 |
Jian Li
(Phelps Lab) Different Reinforcement-Learning Mechanisms Involved in Economic Decision-Making
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Feb 19, 2010 |
No Meeting: Psych C&P Open House
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Feb 26, 2010 |
No Meeting: Psych C&P Open House
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March 5, 2010 3:30 PM–5:00 PM Meyer 815 |
Michael Milham
(Child Study Center) TBA
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March 12, 2010 3:30 PM–5:00 PM Meyer 815 |
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March 19, 2010 3:30 PM–5:00 PM Meyer 815 |
Chris Kaul
(Heeger Lab) TBA
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March 26, 2010 3:30 PM–5:00 PM Meyer 815 |
Dino Levy
(Glimcher Lab)
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April 2, 2010 3:30 PM–5:00 PM Meyer 815 |
Clare Kelly
(Child Study Center)
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April 9, 2010 3:30 PM–5:00 PM Meyer 815 |
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April 16, 2010 3:30 PM–5:00 PM Meyer 815 |
No Meeting: CNS Conference
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April 23, 2010 3:30 PM–5:00 PM Meyer 815 |
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April 30, 2010 3:30 PM–5:00 PM Meyer 815 |
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May 7, 2010 |
No Meeting: VSS Conference
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May 14, 2010 3:30 PM–5:00 PM Meyer 815 |
VSS / ISMRM Recap
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May 21, 2010 3:30 PM–5:00 PM Meyer 815 |
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